As previously reported, we proved NEK2 acting as a MM drug-resistant gene by comparing 9 pairs sequential MM samples that were collected from the same patients at 4 sequential treatment stages, newly-diagnostic, before the 1st autologous stem cell transplantation (ASCT), before the 2nd ASCT and after the 2nd ASCT stages [50]. Here, NEK2 is linked to Miyoshi myopathy.