To identify the mechanism on how AHSA1/HSP90 complex promoted MM cell proliferation and BTZ resistance, we performed a Co-IP assay followed by MS method to determine the proteins interacting with HSP90 in ARP1 WT, AHSA1-OE cells, AHSA1-OE cells treated with Bufalin or BTZ. This evidence concerns the gene HSP90AA1 and Miyoshi myopathy.