CAR-T cell therapy has already achieved tremendous success in the treatment of hematological malignancies resulting in FDA/EMA approvals for CD19-targeting CAR-T cell compounds: Kymriah (DLBCL, ALL), Yescarta (DLBCL, follicular lymphoma), Breyanzi (DLBCL, follicular lymphoma), Tecartus (CML) and Abecma (MM) [137]. This evidence concerns the gene CD19 and hematologic disorder.