The involvement of the CD70-CD27 axis in blastoid formation was also seen in a rare case of low-grade B cell lymphoma, where upregulation of CD70 and CD27 coincided with a highly increased gene expression of galactin 1 and TGF-ß receptor III, suggesting this could be implicated in the MEK and TGF-ß signaling pathway, respectively [80]. The gene discussed is CD27; the disease is B-cell non-Hodgkin lymphoma.