In addition to different CAR-therapies in preclinical development, currently, five anti-CD70 CAR-T based approaches, i.e., anti-hCD70 CAR (NCT02830724), 4SCAR70 (NCT03125577), CAR CD70 (NCT04662294), CTX130 (NCT04438083) and ALLO316 (NCT04696731), are being evaluated in phase I/II clinical trials in patients with hematological and solid malignancies, awaiting results regarding the safety profile and efficacy in these different cancer types. Here, CD70 is linked to cancer.