Compared with participants with low baseline/low increase of hs-CRP, those with high baseline/low increase, low baseline/high increase and high baseline/high increase were 2.17 (1.52, 3.07), 2.55 (2.04, 3.21) and 2.68 (1.40, 4.90) times as likely to have MetS (P for trend < 0.001, Additional file 1: Fig. S3). This evidence concerns the gene CRP and metabolic syndrome.