The significantly (P < 0.001) enriched pathways were related to cytokine-cytokine receptor interaction, PI3K-AKT, TNF signaling, proteoglycans in cancer, MAPK, JAK-STAT, pathways in cancer, apoptosis, NF-κB and transcriptional misregulation in cancers (Fig. 3A). This evidence concerns the gene NFKB1 and cancer.