PPARG and plasma cell myeloma: Our previous study demonstrated that myeloma cells can reprogram bone marrow adipocytes via altered promoter histone methylation of the peroxisome proliferator-activated receptor γ (PPARγ), which reduced expression of PPARγ and a modified adipokine secretion profile, causing enhanced osteoclastogenesis and suppression of osteoblastogenesis in complete remission patient [20].