A week later, fever and dyspnea were relieved, his platelet count recovered to 50 × 109/L, serum T. gondii IgM antibody had increased to 12 AU/mL and IgG antibody had turned positive (7.49 AU/mL), which confirmed the diagnosis of primary T. gondii infection associated HPS. Here, CD40LG is linked to Hermansky-Pudlak syndrome.