RhoB exerts positive effects on increasing expression of estrogen receptor alpha (ER\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\alpha$$\end{document}α) and progesterone receptor (PR), which correlate to the progression of breast cancer [31]. The gene discussed is ESR1; the disease is breast carcinoma.