TSGs such as RASSF1, CDKN2A, DAPK, APC and p14ARF are aberrantly methylated in NSCLC as well as other cancers, namely head and neck cancer (HNC), prostate cancer and cervical cancer [124,125,126,127,128,129,130,131,132]. This evidence concerns the gene CDKN2A and Familial prostate cancer.