This mechanism has also been observed for other targets, since KDM6B was involved in the stabilization of the transcription factor FOXO1 (Forkhead box protein O1, an inducer of pro apoptotic genes BIM, TRAIL, and FasL) in the nucleus of A549 and H460 non-small cell lung cancer cell lines. The gene discussed is FOXO1; the disease is non-small cell lung carcinoma.