SNAI1 and colonic neoplasm: On the contrary, the knock-down of KDM6B or the expression of an inactive KDM6B mutant in SW-480 human colon cancer cells increased the expression of SNAIL1, ZEB1, and ZEB2 EMT ATFs, and led to consecutive decreases in E-CADHERIN, CLAUDIN1, and CLAUDIN7 expressions (epithelial markers) [84].