KDM6B and hepatocellular carcinoma: In the hepatocellular carcinoma cell line, HepG2, KDM6B directly activated SNAI2 transcription via a demethylation of H3K27 on its promoter and KDM6B overexpression promoted EMT, migration and invasion capacities and stem cell-like features (holoclone formation, clonogenic capacities, and sphere establishment) [76].