On the contrary, KDM6B also promoted an epithelial-like phenotype, since, in the pancreatic ductal adenocarcinoma cell line BxPC3 and in xenograft models, KDM6B directly induced the demethylation of the H3K27me3 mark on the CEBPA promoter and induced the expression of this gene. Here, KDM6B is linked to pancreatic ductal adenocarcinoma.