In some studies, polyP upregulated the cytokine interleukin 11 (IL-11) in human osteosarcoma SaOS-2 cells and PPK stimulated the secretion of a well-known inflammatory response mediator interleukin 8 (IL-8) in human embryonic intestine INT407 cells [7,8]. Here, CXCL8 is linked to osteosarcoma.