We examined CD64+ ATMs from visceral adipose tissue (VAT) and s.c. adipose tissue (SAT) from a bariatric surgery cohort with obesity, evaluating correlations with clinical metrics, divergence in CD64+ human ATM subtypes with stratification based on classical markers CD11c and MRC1 (CD206), and alignment of ATM subtype gene expression with existing data. This evidence concerns the gene FCGR1A and obesity due to melanocortin 4 receptor deficiency.