Based on overall expression signatures and our finding that CD11c+ ATMs had the strongest overlap with the monocyte transcriptional signature in obesity, it is tempting to speculate that a lineage based on infiltrating monocytes in humans may first differentiate into CD11c+ ATMs that then later express CD206 and become DP ATMs. This evidence concerns the gene MRC1 and obesity due to melanocortin 4 receptor deficiency.