NOTCH3 and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy: In regard to human diseases, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by NOTCH3 mutations (30), and enhanced NOTCH3 expression in SMCs of small arteries in the lung is associated with pulmonary hypertension (29).