Our data showed that restoration of Casq2 at a median (nonzero) distance of 53.8 μm from the nearest Cntn2-positive (Purkinje) cells was sufficient to prevent arrhythmias, indicating that distal (epicardial) cardiomyocytes, despite lacking Casq2, are not the cellular trigger for CPVT. The gene discussed is CNTN2; the disease is catecholaminergic polymorphic ventricular tachycardia.