Our data showed that restoration of Casq2 at a median (nonzero) distance of 53.8 μm from the nearest Cntn2-positive (Purkinje) cells was sufficient to prevent arrhythmias, indicating that distal (epicardial) cardiomyocytes, despite lacking Casq2, are not the cellular trigger for CPVT. This evidence concerns the gene CASQ2 and catecholaminergic polymorphic ventricular tachycardia.