HOXA9 and neoplasm: To understand the role of LAP in the tumor microenvironment of AML, LAP–/– mice lacking the linker and WD domains of Atg16L1 (Supplemental Figure 2 and ref. 39), which are required for LAP, but not canonical, autophagy (Atg16L1E230–), were injected with MN1 or MEIS1/HOXA9 cells.