Furthermore, Atg16L1E230– AML-engrafted animals had increased annexin V+ debris compared with WT Atg16L1E230+ controls with AML, indicating a defect in the clearance of ABs and ACs in the BM of the Atg16L1E230– animals (Figure 3B). The gene discussed is ANXA5; the disease is acute myeloid leukemia.