In the present study, we unveil LINC02362 as a novel tumor-inhibitory lncRNA by directly sponging miR-516b-5p and indirectly increasing the levels of SOCS2, leading to the attenuation of proliferation and metastasis as well as the augment of apoptosis in HCC cells (Figure 12). The gene discussed is SOCS2; the disease is hepatocellular carcinoma.