Together, this brain and lung metastasis data suggested that ABAT-low primary breast tumors (often with concurrent high ALDH1A3 expression) are highly metastatic and are agnostic to whether the metastatic site is enriched for GABA (i.e., the brain) or is depleted for GABA (i.e., the lung). Here, ALDH1A3 is linked to breast neoplasm.