Lyv et al. found that ZFPM2-AS1 was significantly upregulated in RB, and the downregulation of ZFPM2-AS1 restrained the development of RB by regulating miR-515/homeobox A1 (HOXA1)/Wnt/β-Catenin pathway [14]. This evidence concerns the gene ZFPM2 and retinoblastoma.