Our previous studies reported that FGF21 can inhibit hypoxia‐induced PASMC proliferation and migration by upregulating Peroxisome proliferator‐activated receptor gamma (PPARγ), promoting apoptosis and thereby downregulating inflammatory cytokine levels, improving collagen deposition in the lung and attenuating hypoxia‐induced PAH.10, 11. This evidence concerns the gene FGF21 and pulmonary arterial hypertension.