GSEA results revealed that the hallmarks of complement, epithelial–mesenchymal transition, IL-2-STAT5 signaling, hypoxia, coagulation, TNFA signaling via NFκB, interferon-γ response, inflammatory response, allograft rejection and PI3K-AKT-mTOR signaling were significantly enriched in high-DNAJC10 gliomas. Here, AKT1 is linked to central nervous system cancer.