NFKB1 and posterior cortical atrophy: Notably, while constitutive NF-κB signaling, a canonical IL-1-induced intracellular pathway, promotes PCa castration resistance [20,21], the LNCaP and MDA-PCa-2b sublines do not show constitutive upregulation of canonical NF-κB target genes, suggesting that chronic IL-1 can drive NF-κB-independent PCa disease.