In this study, we compared our RNA sequencing and bioinformatics analysis of LNCaP and MDA-PCa-2b sublines isolated from cultures chronically exposed for several months to IL-1 to identify the conserved and divergent gene expression changes and predicted pathways that are known to promote tumorigenicity, and thus, could underlie chronic IL-1-induced PCa progression and serve as novel therapeutic targets. Here, IL1A is linked to posterior cortical atrophy.