MYC and cancer: It is interesting to note that each of the six hallmarks of cancer has been previously associated with oncogene promoter G4 or i-motif structures: self-sufficiency (c-MYC and KRAS), limitless replication (hTERT) (89–92,132), evasion of apoptosis (BCL-2) (56,77–79,133,134), sustained angiogenesis (VEGF) (105,135–139), invasive and metastatic potential (PDGFA) (140) and insensitivity to anti-growth signals (pRb) (66,141).