FUS and amyotrophic lateral sclerosis: In addition, we were able to show that hFUS protein correctly localizes to the nucleus (Figure 6E), in contrast to localization in FUS-ALS and FUS-FTD patients, where FUS protein is found to aggregate in the cytoplasm (Kwiatkowski et al., 2009; Urwin et al., 2010; Vance et al., 2009).