We and others have made KI lines for the key ALS genes Sod1 (Joyce et al., 2015), Tardbp (Fratta et al., 2018), and Fus (Devoy et al., 2017) — all with late onset motor neuron degeneration — that have been used for dissection of ALS disease mechanisms. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.