FUS and amyotrophic lateral sclerosis: The human 3′ UTR was included because (1) variants in the 3′ UTR have been linked to risk for developing ALS (Dini Modigliani et al., 2014; Sabatelli et al., 2013) and (2) ALS-frameshift mutations at the 3′ end of FUS incorporate sequence from the human 3′ UTR and if not humanized, such mutations would result in longer 3′neopeptides that may impact pathogenicity (An et al., 2020).