To understand the effects of DMB on BMD, mTSS, ES, joint space narrowing score (JSNS), DAS28-ESR, simple disease activity index (SDAI), bone turnover markers [type I procollagen N-terminal propeptide (P1NP) and tartrate-resistant acid phosphatase-5b (TRACP-5b)] and the risk of bone fracture and upper respiratory infection in patients with RA, we carried out a systematic review of original articles that reported such information in patients with RA treated with DMB and made a quantitative summary of the accumulated evidence on the efficacy of DMB for RA by performing a meta-analysis. The gene discussed is ACP5; the disease is respiratory tract infectious disorder.