Severity of CS (OR = 2.4; 95% CI, 1.1-4.9) and ACTH-dependent CS (OR = 2.9; 95% CI, 1.3-6.4), but not the type of hyperglycemia (DM vs prediabetes: OR = 2.13 [95% CI of 0.9-4.9]), were found to be associated with hyperglycemia improvement on multivariable analysis (see Table 4). The gene discussed is POMC; the disease is Cowden syndrome 1.