The Siglec-15 preferentially recognizes the sTn antigen, a tumor-associated glycan structure, and the coculture of Siglec-15+ myeloid cell line and sTn+ cancer cell line enhances the myeloid cell production of transforming growth factor-b (TGF-b) (a pleiotropic cytokine that promotes epithelial-mesenchymal transition and metastasis of cancer cells), which is dependent on DAP12 and SYK [16]. This evidence concerns the gene TGFB1 and cancer.