The association of endurance exercise and ACM pathogenesis in the setting of desmosome deleterious variants was established using transgenic mouse model with heterozygous plakoglobin knock out (Jup+/−), demonstrating that the development of right ventricular dysfunction and arrhythmias were accelerated by endurance training in Jup+/− mice (131). The gene discussed is JUP; the disease is cardiac arrhythmia.