In addition, other proteins involved in Ca2+ signaling include calsequestrin 2 (CSQ2) and matrix interacting molecule 1 (STIM1), as well as fibroblast growth factor 23 (FGF23), which directly causes cardiovascular problems in patients, and proprotein convertase subtilisin 9 (PCSK9), which is related to LDL-cholesterol disorders, which are all key links in the process of Fam20C affecting heart disease (Ezumba et al., 2014; Pollak et al., 2017; Pollak et al., 2018; Ben Djoudi Ouadda et al., 2019). This evidence concerns the gene FGF23 and heart disorder.