The altered infiltration levels of immune cells, including B cells, CD8+T cells, CD4+T cells, macrophages, neutrophils, and dendritic cells were considered to be responsible for its correlation with cancers, while the expression of FAM20C also assisted the polarization of tumor-associated macrophages (TAM), activation of Treg cells and T helper cells, and induction of T-cell exhaustion (Liu et al., 2021). Here, FAM20C is linked to cancer.