LINC01224, LINC01138, and MKLN1-AS affect the progression of HCC by regulating miRNAs; the upregulation of C2orf27 A was found to be related to resistance to sorafenib in HCC; POLH-AS1 mutation is associated with the occurrence and development of many diseases, but it has not been reported in HCC (Flanagan et al., 2007; Jiang et al., 2019; Gong D. et al., 2020; Gao et al., 2020; Kong et al., 2020; Yuan et al., 2021). The gene discussed is MKLN1; the disease is hepatocellular carcinoma.