In this line, we aimed to assess the distribution of polymorphisms in genes encoding glutathione transferases alpha (GSTA1), mu (GSTM1, GSTM3), pi (GSTP1 rs1695 and GSTP1 rs1138272), and theta (GSTT1) in COVID-19 patients and matched healthy individuals, emphasizing their individual and cumulative effect in disease development. This evidence concerns the gene GSTM1 and COVID-19.