The cancer stem cell-like features of pancreatic ductal adenocarcinoma are maintained by the autocrine stimulation of extracellular interferon-stimulated gene 15 (ISG15), which is modulated by TRIM29 via Calpain-3 (CAPN3)-mediated posttranslational degradation (70). This evidence concerns the gene TRIM29 and pancreatic ductal adenocarcinoma.