MASP1 and Cowden disease: Interestingly, vaccine candidate containing MASP was tested in an experimental model of acute CD and induces a balanced proinflammatory/regulatory (IFN-γ, IL-12, IL-17, and IL-10) immune response, promoting host survival, and reducing parasite load in the heart, liver, and spleen (Serna et al., 2014) but not clearing the infection.