Furthermore, T lymphocyte is likely to have interaction with neural stem cells, thus inhibiting its proliferation and resulting in age-related brain disease (Dulken et al., 2019); the abnormal level of m5C, another form of RNA methylation, in CD4+ T lymphocytes may have a potential link with the pathogenesis of systemic lupus erythematosus (SLE) (Guo G et al., 2020). This evidence concerns the gene CD4 and systemic lupus erythematosus.