Examples are PICALM/CALM contributing to Alzheimer’s disease pathology (Moreau et al., 2014), C9ORF72 implicated in ALS and FTD (Farg et al., 2014) and several genes linked to Parkinson’s disease such as LRRK2, VPS35, SNCA, Synj1 and EndoA (Volpicelli-Daley et al., 2014; Zavodszky et al., 2014; Soukup et al., 2016; Vanhauwaert et al., 2017). The gene discussed is SNCA; the disease is early-onset autosomal dominant Alzheimer disease.