SACM1L and Parkinsonism: Specifically, a mutation in the SAC1 domain also found in Parkinson patients, inhibits the dephosphorylation of PI(3)P/PI(3,5)P2 on autophagosomal membranes, resulting in the accumulation of the PI(3)P-binding protein ATG18a/WIPI2 on the membrane of nascent autophagosomes, and the consecutive failure in ATG8/LC3 recruitment (Vanhauwaert et al., 2017).