SMN1 and cancer: The first, myofibroblastic PSC, are associated with elevated a-SMA expression in immediately surrounding of cancer cells, and produce large amounts of pro-fibroproliferative collagen fibers, while the second type, inflammatory PSC, are not associated with elevated a-SMA expression, but are known to secrete large amounts of inflammatory cytokines further away from the cancer cells (Öhlund et al., 2017).