HMGB3 and neuroblastoma: In addition, according to the immunocytochemical analysis, Ki-67 nuclear expression was downregulated in the HMGB3-depleted NB cell lines SK-N-SH (n = 6, p < 0.01) and SK-N-AS (n = 6, p < 0.001) compared to the control groups (Figure 3B), indicating that NB proliferation was suppressed upon HMGB3 knockdown.