The high expression of LEF1-AS1 is associated with the low survival rate of patients with cancers such as glioma, osteosarcoma, lung cancer, ovarian cancer, colorectal cancer, esophageal squamous cell carcinoma, etc., suggesting that LEF1-AS1 can be used as a biomarker for early detection and prognostic evaluation. The gene discussed is LEF1; the disease is osteosarcoma.