Chen et al. pointed out that the TCGA database and the comparison of cancerous and paracancerous tissues of 40 patients with glioma showed that LEF1-AS1 was significantly upregulated in cancer tissues, and this was significantly associated with the poor survival rate of GBM patients, indicating the potential malignancy roles of LEF1-AS1 in glioma (Cheng Z. et al., 2020). This evidence concerns the gene LEF1 and cancer.