HK1 and triple-negative breast carcinoma: Recent transcriptomic analysis of a triple-negative breast cancer dataset (Curtis et al., 2012) illustrated that elevated gene expression of multiple key glycolytic enzymes, including lactate dehydrogenase A (LDHA), hexokinase-1 (HK1), and pyruvate kinase muscle isozyme 2 (PKM2) positively correlated with increased abundance of intratumoral MDSC (Li et al., 2018).