FASN and hepatocellular carcinoma: In ovarian cancer and hepatocellular carcinoma, the key enzyme of de novo lipogenesis, fatty acids synthase (FASN), is overexpressed and produces an excessive amount of fatty acids, which can be ingested by DC via scavenging receptors (macrophage scavenger receptor 1 and CD204) and stored inside DC as lipid droplets (Jiang et al., 2018; Hu et al., 2020b).