CPT1A and neoplasm: Compared to their splenic counterparts, tumor MDSCs reprogram their lipid metabolic profile by increasing fatty acids uptake and oxidation, which augments mitochondrial mass; increases oxygen consumption rate (OCR); and upregulates key enzymes involved in fatty acid oxidation (FAO), including CPT1, acyl CoA dehydrogenase (ACADM), peroxisome proliferator-activated receptor-gamma coactivator 1-β (PGC1β), and 3-hydroxyacyl-CoA dehydrogenase (HADHA) (Hossain et al., 2015).