Here, we investigated two unrelated Chinese families with NF-1 characterized by early-onset hypertension by whole-exome sequencing and Sanger sequencing and identified one recurrent NF1 variant c.6789_6792delTTAC and one novel heterozygous mutation c.6934_6936delGCAinsTGCT in families 1 and 2, respectively. Here, NF1 is linked to hypertensive disorder.