In five of the studies (16–20, 22), the patients were children and young adults (1.5–25 years) with a high prevalence of early-onset hypertension, suggesting the necessity of regular blood pressure monitor in young patients with NF-1, and the patients in the study conducted by Zinnamosca et al. (21) were middle-aged adults. This evidence concerns the gene NF1 and Hypertension.