As presented in Table 1, the current review study identifies 22 IHC biomarkers as diagnostic tools for pancreatic cancer that embrace: Pentraxin-3, ENO1, REG4, POSTN, CA125, CA242, Galectin-1, Galectin-9, Maspin, pVHL, MUC1, MUC5AC, THBS2, LTBP2, CPA4, IMP3, CD13, Dkk1, KOC, S100P, Mesothelin, PAM4. Here, S100P is linked to familial pancreatic carcinoma.