Table 1 further demonstrates that, except four IHC biomarkers (CA125, THBS2, MUC5AC, Dkk1) whose efficacy in discriminating pancreatic cancer from healthy cases have not been investigated or reported, 18 remaining IHC biomarkers analyzed (81.8%) can differentiate pancreatic cancer, especially PDAC, from healthy or normal cases. Here, THBS2 is linked to familial pancreatic carcinoma.