Through our review, promising IHC biomarkers for pancreatic cancer diagnosis in terms of sensitivity and specificity comprise: maspin (sensitivity/specificity: 87.5/100), pVHL (sensitivity/specificity: 100/81.8), KOC (sensitivity/specificity: 84/100), S100P (sensitivity/specificity: 83/100), galectin-1 (sensitivity/specificity: 82.8/100), THBS2 (sensitivity/specificity: 87/98), mesothelin (sensitivity/specificity: 88/92), and IMP3 (sensitivity/specificity: 85/90). Here, VHL is linked to familial pancreatic carcinoma.