RUNX1 and leukemia: However, a retrospective study of 105 children, 22 of whom were positive for the ETV6/RUNX1 gene treated with the Dutch Collaborative Childhood Leukemia Study Group-VIII protocol (DCLSG-VIII), found that this fusion gene is an independent prognostic factor that was lacking in children treated with DCLSG-VIII, and children with this subtype did not have a better prognosis than other subtypes (7).