RUNX1 and acute lymphoblastic leukemia: In the present study, it was also observed that the prednisone response and bone marrow MRD on Day 33 of induction chemotherapy were better in ETV6/RUNX1-positive children with ALL than in ETV6/RUNX1-negative cases, indicating a good early treatment response and a high rate of bone marrow CR in ETV6/RUNX1-positive children.