The results showed that ETV6/RUNX1-positive cases on the SCCLG-ALL-2016 protocol, age ≥1 years and <10 years, and PGR and D-15 MRD negative had better EFS and OS than those on the GD-ALL-2008 protocol, age <1 or ≥10 years, and PPR and D-15 MRD positive, respectively (Figures 4A, B). This evidence concerns the gene RUNX1 and acute lymphoblastic leukemia.