Clinical characteristics of our cohort of ETV6/RUNX1-positive ALL children included age at childhood onset mostly distributed between 1 and 10 years (94.6%), with a median age of 4.2 years and no infantile leukemia; median initial WBC of 8.6 × 109/L and <10 × 109/L in 56.2%; mostly combined with moderate anemia and thrombocytopenia; immunophenotype of common B-ALL was predominant (71.6%); the risk classification was only 9.8% in the high-risk group, which is largely consistent with what has been reported in most previous studies (14, 15, 17–23). This evidence concerns the gene RUNX1 and leukemia.