Recently, it has been reported that hyperglycemia promotes chemoresistance by decreasing mitochondrial DNA damage, Bax/Bcl-2 and Bax/Bcl-XL ratios, and sub-G1 phase cells associated with antitumor drug-induced cytotoxicity in human colon adenocarcinoma cells (13). The gene discussed is BCL2L1; the disease is colon adenocarcinoma.