CCR2 and neoplasm: Indeed, these studies suggest that the major monocyte recruiting pathways (M-CSF/CSF-1R, CCL2/CCR2, CCL3/CCR1, CCL3/CCR5, CCL5/CCR5 and CX3CL1/CX3CR1) enable tumor survival by supplying the TME with pro-tumorigenic TAMs.