For example, the CCL3/CCR1 axis was found to mediate macrophage recruitment during the formation of early metastatic niches in a mouse E0771-LG breast cancer model (66, 69), and CCL3/CCR5 mediated macrophage recruitment to the metastatic site in murine Renca renal cell carcinoma model (70). Here, CCL3 is linked to breast cancer.