HSP90B1 and breast cancer: By performing Real-Time qPCR (Figure 6A) and Western Blot analysis (Figures 6B, C), we verified that hypoxia promoted gp96 generation (Fold changes: 3.22 and 4.01) and secretion (Fold changes: 2.34 and 2.91) in the PS-BC cells and supernatants, which were reversed by silencing HIF-1, suggesting that hypoxia promoted intracellular and extracellular gp96 expressions through inducing HIF-1 expressions.