In addition, we noticed that PR-BC-exo induced upregulation of cellular cytokines, including IL-1β and IL-18, in both CD8+ T cells (Fold changes: 3.45 and 4.32, Figure 5A) and its supernatants (Fold changes: 5.22 and 4.71, Figure 5B), as determined by Real-Time qPCR and ELISA. The gene discussed is CD8A; the disease is breast cancer.