In addition, the plasma exosomes were isolated and purified from the above BC patients’ blood samples, the morphology of the exosomes was photographed by performing the TEM assay (Figure S1A), and further Western Blot analysis verified that the exosome markers, including CD63 and TSG101, were expressed, but the cellular indicator β-actin was absent in the isolated exosomes (Figure S1B), implying that the quality of the exosomes were guaranteed. This evidence concerns the gene ACTB and breast cancer.