HSP90B1 and breast cancer: To validate the biological functions of gp96, we conducted the following functional experiments and evidenced that overexpression of gp96 increased paclitaxel-resistance in PS-BC cells, whereas gp96 ablation sensitized PR-BC cells to paclitaxel treatments, suggesting that gp96 promoted paclitaxel-resistance in BC, which were supported by the previous publications (10–12).