In addition, previous literatures report that cancer cells derived exosomes interact with immune cells to promote immune evasion during cancer pathogenesis (37–39), and researchers notice that gp96 is considered as biomarker for immune surveillance via influencing CD4+ and CD8+ T-lymphocytes (9, 40), which are supported by our results that gp96-containing exosomes suppressed cell viability in the CD8+ T cells, which is the main immune cells that recognize tumor antigens (35, 36). This evidence concerns the gene CD4 and cancer.