PTGS2 and neoplasm: The reduction in cAMP levels induced by GABA therapy prevents tumor progression and signaling protein activation (104).GABA and Celecoxib downregulate the expression of the COX-2 protein and P-5-LOX, inhibits the development of xenotransplants, and reduce the systemic and tumor levels of VEGF, PGE2, and cAMP and phosphorylated signaling proteins (22).