IGF1 and colorectal carcinoma: Zhang et al., on the other hand, conducted a similar study to investigate the role of IGF-1 and its receptor (IGF1R) in colorectal carcinoma and discovered comparable results that high circulating IGF1 levels and mucosal IGF1R expression may play a significant role in both the formation and development of colorectal carcinoma and may encourage the growth and malignant transformation of adenomatous polyps [37].