While this study demonstrated a critical role of NF-κB in cell survival via its antioxidant function, the classical NF-κB targets such as COX2 and iNOS are also known to promote the survival of colon cancer cells [47, 48]; therefore, further studies are needed to determine the other NF-κB targets that also contribute to cell survival under acidosis. The gene discussed is NFKB1; the disease is malignant colon neoplasm.