In summary, curcumin and aerobic exercise (irisin) can alleviate hyperandrogenism-induced ER stress and suppress the IRE1α-XBP1 pathway, which prevented ovarian GC apoptosis in PCOS-like rats, leading to the improvement in the ovarian microenvironment and promotion of follicular development. The gene discussed is XBP1; the disease is hyperandrogenism.