In the present study, a 3D cell culture model and in vivo rat tail compression model were constructed, and analyses of these models revealed that SIRT1 overexpression can increase formation of the LC3B/Fas complex, which contributes to suppression of NPC apoptosis under high-magnitude compression through inhibition of the NF-κB pathway (Figure 7). Here, NFKB1 is linked to nasopharyngeal carcinoma.