Higher FABP4 value has been associated with metabolic syndrome, inflammation, development of atherosclerosis, and insulin resistance [26, 43], and thus, various metabolic changes due to iron toxicity [5, 17, 18] may be accompanied by an increase in FABP4 level and simultaneously promote an increase in LAVI and E/E′ ratio. The gene discussed is FABP4; the disease is Insulin resistance.