A specific G-CIMP has been identified in glioma, featured with somatic IDH1/2 mutation, lack of chr.7 amplification, obvious amplification of 8q23.1-24.3 and 10p15.3-p11.21, and prevalence in low-grade glioma but not GBM 13, 20. The gene discussed is IDH1; the disease is glioblastoma.