Together, these data revealed common features of GBM, including gain of chr.7 and loss of chr.10, lacking IDH1/2 mutations, high frequency of TERT promoter mutation, loss of critical tumor suppressors (e.g., PTEN and CDKN2A/CDKN2B), high frequency of PDGFA and EGFR amplification. The gene discussed is PTEN; the disease is neoplasm.